Cascade is a historic neighborhood abutting Downtown Seattle, Washington, USA; it constitutes the eastern portion of what has come to be known as Cascade Neighborhood. The neighborhood, one of Seattle's oldest. Cascade grew up in the late 19th and early 20th century as a blue-collar neighborhood with a mixture of housing and one of the city's first industrial areas.

Like most of Seattle, the Cascade Neighborhood was originally heavily forested. In the 1860s, David Denny and Thomas Mercer first claimed portions of this land. However, initial development was a bit west of Cascade, at southwest Lake Union, which became a transportation nexus and where Denny established the lake's first sawmill. By the 1880s, more mills and more cleared land led to the origin of Cascade as a residential and industrial neighborhood, tied into water transportation.